Everton's squad will be tested strongly after their marathon League Cup defeat against Chelsea on Wednesday, and will be without influential loanee Royston Drenthe - who has looked the Toffees' most dangerous player in recent weeks - following his red card in extra time.
David Moyes is more than likely to adopt a 4-5-1 formation, which the Goodison Park boss favours due to a shortage of strikers at the club, following the sale of Jermaine Beckford and injury to Victor Anichebe. Louis Saha looks set to lead the line against his former team, with ex-Red Devil Phil Neville and midfielder Tim Cahill both possible doubts after picking up knocks midweek.
Sir Alex Ferguson has a number of options to choose from following Manchester United's 3-0 victory over Aldershot, which essentially featured a side of reserve players. Michael Owen and Dimitar Berbatov are likely to miss out on a place in the starting XI despite their strong showing on Tuesday. Expect Sir Alex to revert to the pairing of Chicharito and former Everton striker Wayne Rooney, with the latter set for an acrimonious welcome, as per usual at Goodison Park.
In central midfield, Sir Alex may favour changing things up after last week's debacle against Manchester City, with Michael Carrick likely to replace Anderson, although Darren Fletcher is set to start with Tom Cleverley still only just returning from injury.